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Alzheimer’s disease (Late onset)

DOID EFO MESH SNOMED PheWeb

AD_LO

Alzheimer's disease: A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 F00.1*, F00.10*, F00.10*G30.1, G30.1, G30.1+F00.10
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 F00.1*, F00.10*, F00.10*G30.1, G30.1, G30.1+F00.10
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

5516

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5516

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Check minimum number of events None

5516

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Include endpoints None

5516

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AD_LO

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 5516 2393 3123
Unadjusted prevalence (%) 1.55 1.21 1.98
Mean age at first event (years) 80.02 80.33 79.78

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.16 9.52 [8.10, 11.20] <1e-100 2941
15 years 0.02 2.59 [2.18, 3.07] 5.1e-28 729
5 years 0.01 6.27 [5.45, 7.20] <1e-100 1263
1 year 0.00 17.14 [15.01, 19.58] <1e-100 941

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: AD_LO – Alzheimer’s disease (Late onset)
GWS hits:

Survival analyses between endpoints

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Plot

before Alzheimer’s disease (Late onset)
after Alzheimer’s disease (Late onset)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Alzheimer’s disease (Late onset)

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