Acute appendicitis, with complications

APPENDACUT_COMPLIC

appendicitis: Acute inflammation of the vermiform appendix.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K35.0, K35.1
Hospital discharge: ICD-9 540[0-1]
Hospital discharge: ICD-8 540
Hospital discharge: excluded ICD-8 54090|54099
Cause of death: ICD-10 K35.0, K35.1
Cause of death: ICD-9 540[0-1]
Cause of death: ICD-8 540
Cause of death: excluded ICD-8 54090|54099

10526

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6250

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Check minimum number of events None

6250

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Include endpoints None

6250

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APPENDACUT_COMPLIC

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 6250 2966 3284
Unadjusted prevalence (%) 1.76 1.49 2.09
Mean age at first event (years) 36.40 34.04 38.53

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.86 [0.63, 1.18] 3.6e-1 663
15 years 0.00 0.73 [0.56, 0.95] 1.8e-2 291
5 years 0.00 1.09 [0.84, 1.43] 5.0e-1 106
1 year 0.00 2.38 [1.67, 3.40] 1.9e-6 41

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: APPENDACUT_COMPLIC – Acute appendicitis, with complications
GWS hits: 2

Survival analyses between endpoints

Plot

before Acute appendicitis, with complications
after Acute appendicitis, with complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Acute appendicitis, with complications