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Non-allergic asthma

DOID EFO MESH SNOMED PheWeb

ASTHMA_NONALLERG

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

not L12_ATOPIC
and not ALLERG_RHINITIS
and not H7_ALLERGICCONJUNCTIVITIS
and not FOOD_ALLERGY
and not Z21_DESEN_ALLERGE
and not POLLENALLERG

320743

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

5578

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ASTHMA_NONALLERG

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 5578 3173 2405
Unadjusted prevalence (%) 1.57 1.60 1.53
Mean age at first event (years) 50.76 48.63 53.57

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.00 [1.52, 2.63] 7.8e-7 751
15 years 0.01 1.52 [1.22, 1.89] 2.3e-4 384
5 years 0.00 2.54 [2.06, 3.13] 1.6e-18 201
1 year 0.00 4.40 [3.29, 5.89] 2.6e-23 66

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ASTHMA_NONALLERG – Non-allergic asthma
GWS hits:

Survival analyses between endpoints

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Plot

before Non-allergic asthma
after Non-allergic asthma

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Non-allergic asthma

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