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Asthma

DOID EFO MESH SNOMED PheWeb

J10_ASTHMA

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 J45, J46
Hospital discharge: ICD-9 493
Hospital discharge: ICD-8 493
Cause of death: ICD-10 J45, J46
Cause of death: ICD-9 493
Cause of death: ICD-8 493

38560

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

38555

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Check minimum number of events None

38555

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Include endpoints None

38555

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J10_ASTHMA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 38555 23479 15076
Unadjusted prevalence (%) 10.84 11.83 9.58
Mean age at first event (years) 44.93 43.32 47.43

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.07 [1.80, 2.39] 9.9e-24 4260
15 years 0.01 1.39 [1.24, 1.56] 3.2e-8 1855
5 years 0.00 2.54 [2.29, 2.81] 3.0e-71 1074
1 year 0.00 5.71 [4.99, 6.53] <1e-100 467

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: J10_ASTHMA – Asthma
GWS hits:

Survival analyses between endpoints

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Plot

before Asthma
after Asthma

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