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Non-allergic asthma (mode)

DOID EFO MESH SNOMED PheWeb

NONALLERG_ASTHMA

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 J45.1
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 J45.1
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

34927

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Check pre-conditions, main-only, mode, ICD version

Check mode of ICD-10 codes: %J451
Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6637

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Check minimum number of events None

6637

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Include endpoints None

6637

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NONALLERG_ASTHMA

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 6637 3938 2699
Unadjusted prevalence (%) 1.87 1.98 1.72
Mean age at first event (years) 49.09 47.36 51.61

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.11 [1.51, 2.94] 1.1e-5 807
15 years 0.01 1.51 [1.15, 1.99] 3.2e-3 410
5 years 0.00 2.65 [2.11, 3.33] 5.5e-17 215
1 year 0.00 4.53 [3.36, 6.12] 5.5e-23 70

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: NONALLERG_ASTHMA – Non-allergic asthma (mode)
GWS hits:

Survival analyses between endpoints

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Plot

before Non-allergic asthma (mode)
after Non-allergic asthma (mode)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Non-allergic asthma (mode)

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