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Brain glioblastoma

DOID EFO MESH SNOMED PheWeb

C3_GBM

brain glioblastoma: A WHO grade IV malignant astrocytic tumor that arises from the brain, usually the cerebral hemispheres. It is characterized by the presence of poorly differentiated astrocytes, cellular polymorphism, nuclear atypia, and increased mitotic activity. The prognosis is poor.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

HLP_C3_GBM

178

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Filter registries

Cause of death: ICD-10 C71
Cause of death: ICD-9 191
Cause of death: ICD-8 191
Cancer registry: Topography ICD-O-3 C71
Cancer registry: Morphology ICD-O-3 9440
Cancer registry: Behaviour codes 3

178

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

178

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Check minimum number of events None

178

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Include endpoints

178

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C3_GBM

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Summary Statistics

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Key figures

All Female Male
Number of individuals 178 74 104
Unadjusted prevalence (%) 0.05 0.04 0.07
Mean age at first event (years) 64.05 64.53 63.71

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_GBM – Brain glioblastoma
GWS hits:

Survival analyses between endpoints

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Plot

before Brain glioblastoma
after Brain glioblastoma

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Brain glioblastoma

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