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Brain medulloblastoma

DOID EFO MESH SNOMED PheWeb

C3_MEDULLOBLASTOMA

medulloblastoma: A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

HLP_C3_MEDULLOBLASTOMA

10

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Filter registries

Cause of death: ICD-10 C71
Cause of death: ICD-9 191
Cause of death: ICD-8 191
Cancer registry: Topography ICD-O-3 C71
Cancer registry: Morphology ICD-O-3 9470
Cancer registry: Behaviour codes 3

10

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints

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C3_MEDULLOBLASTOMA

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Summary Statistics

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Key figures

All Female Male
Number of individuals 10 9 -
Unadjusted prevalence (%) 0.00 0.00 -
Mean age at first event (years) 14.56 16.12 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: C3_MEDULLOBLASTOMA – Brain medulloblastoma
GWS hits:

Survival analyses between endpoints

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Plot

before Brain medulloblastoma
after Brain medulloblastoma

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Drugs most likely to be purchased after Brain medulloblastoma

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