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Chron's disease NAS

DOID EFO MESH SNOMED PheWeb

CHRONNAS

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K50.9
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K50.9
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

1823

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1823

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Check minimum number of events None

1823

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Include endpoints None

1823

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CHRONNAS

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K50
Name in latin Morbus Crohn non specificatus

Summary Statistics

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Key figures

All Female Male
Number of individuals 1823 996 827
Unadjusted prevalence (%) 0.51 0.50 0.53
Mean age at first event (years) 44.50 43.05 46.25

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 5.47 [3.53, 8.46] 2.7e-14 125
15 years 0.02 2.28 [1.46, 3.57] 3.1e-4 42
5 years 0.01 5.84 [4.02, 8.47] 1.7e-20 45
1 year 0.00 15.70 [9.79, 25.17] 2.8e-30 30

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: CHRONNAS – Chron's disease NAS
GWS hits: 5

Survival analyses between endpoints

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Plot

before Chron's disease NAS
after Chron's disease NAS

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Chron's disease NAS

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