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Crohn disease

DOID EFO MESH SNOMED PheWeb

K11_CROHN

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K50
Hospital discharge: ICD-9 555
Hospital discharge: ICD-8 5630
Cause of death: ICD-10 K50
Cause of death: ICD-9 555
Cause of death: ICD-8 5630

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

3766

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K11_CROHN

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K50-K52
Name in latin Morbus Crohn

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 3766 2089 1677
Unadjusted prevalence (%) 1.06 1.05 1.07
Mean age at first event (years) 42.76 41.11 44.82

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.73 [2.63, 5.29] 1.6e-13 211
15 years 0.01 1.88 [1.33, 2.66] 3.3e-4 80
5 years 0.00 3.63 [2.40, 5.49] 1.1e-9 60
1 year 0.00 9.87 [6.32, 15.42] 8.8e-24 35

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_CROHN – Crohn disease
GWS hits:

Survival analyses between endpoints

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Plot

before Crohn disease
after Crohn disease

loading spinner Loading survival analyses plot