≡ Risteys
R8

Documentation Changelog GitHub Contact & Feedback

Secondary systemic amyloidosis

DOID EFO MESH SNOMED PheWeb

E4_AMYL_SCNDSYST

amyloidosis: A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.

Endpoint definition

↥
FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector

Check conditions None

356077

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 E85.3
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E85.3
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

82

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

82

diagram downward connector

Check minimum number of events None

82

diagram downward connector

Include endpoints None

82

diagram downward connector
E4_AMYL_SCNDSYST

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E85
Name in latin Amyloidosis systemica secundaria

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 82 50 32
Unadjusted prevalence (%) 0.02 0.03 0.02
Mean age at first event (years) 59.92 58.52 62.10

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: E4_AMYL_SCNDSYST – Secondary systemic amyloidosis
GWS hits:

Survival analyses between endpoints

↥

Plot

before Secondary systemic amyloidosis
after Secondary systemic amyloidosis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Secondary systemic amyloidosis

↥