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Amyloidosis

DOID EFO MESH SNOMED PheWeb

E4_AMYLOIDOSIS

amyloidosis: A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E85
Cause of death: ICD-10 E85

814

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

450

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Check minimum number of events None

450

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Include endpoints

461

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E4_AMYLOIDOSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E70-E90
Name in latin Amyloidosis

Similar endpoints

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List of similar endpoints to Amyloidosis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 461 231 230
Unadjusted prevalence (%) 0.13 0.12 0.15
Mean age at first event (years) 62.71 59.10 66.34

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_AMYLOIDOSIS – Amyloidosis
GWS hits:

Survival analyses between endpoints

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Plot

before Amyloidosis
after Amyloidosis

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