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Congenital iodine-deficiency syndrome/hypothyroidism

DOID EFO MESH SNOMED PheWeb

E4_CONGEIOD

thyroid disease: A disease involving the thyroid gland.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E00, E03.0, E03.1
Hospital discharge: ICD-9 243
Hospital discharge: ICD-8 243
Cause of death: ICD-10 E00, E03.0, E03.1
Cause of death: ICD-9 243
Cause of death: ICD-8 243

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

832

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E4_CONGEIOD

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 832 653 179
Unadjusted prevalence (%) 0.23 0.33 0.11
Mean age at first event (years) 55.62 53.96 61.68

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.39 [1.39, 8.27] 7.3e-3 119
15 years 0.01 1.13 [0.43, 2.93] 8.0e-1 38
5 years 0.00 2.97 [1.45, 6.09] 2.9e-3 46
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_CONGEIOD – Congenital iodine-deficiency syndrome/hypothyroidism
GWS hits: 3

Survival analyses between endpoints

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Plot

before Congenital iodine-deficiency syndrome/hypothyroidism
after Congenital iodine-deficiency syndrome/hypothyroidism

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Congenital iodine-deficiency syndrome/hypothyroidism

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