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Type 1 diabetes with ketoacidosis

DOID EFO MESH SNOMED PheWeb

E4_DM1KETO

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E10.1
Hospital discharge: ICD-9 2501B
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E10.1
Cause of death: ICD-9 2501B
Cause of death: ICD-8 $!$

1935

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1935

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Check minimum number of events None

1935

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Include endpoints None

1935

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E4_DM1KETO

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3
Parent code in ICD-10 E10

Summary Statistics

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Key figures

All Female Male
Number of individuals 1935 982 953
Unadjusted prevalence (%) 0.54 0.49 0.61
Mean age at first event (years) 25.62 24.59 26.68

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.17 11.13 [6.20, 19.97] 6.4e-16 202
15 years 0.05 7.49 [4.51, 12.42] 6.7e-15 77
5 years 0.02 14.99 [9.08, 24.75] 3.6e-26 45
1 year 0.01 67.67 [41.11, 111.39] 1.1e-61 39

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1KETO – Type 1 diabetes with ketoacidosis
GWS hits: 13

Survival analyses between endpoints

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Plot

before Type 1 diabetes with ketoacidosis
after Type 1 diabetes with ketoacidosis

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Drugs most likely to be purchased after Type 1 diabetes with ketoacidosis

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