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Type 1 diabetes with neurological complications

DOID EFO MESH SNOMED PheWeb

E4_DM1NEU

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E10.4+, E10.4+G59.0, E10.4+G63.2, E10.4+G73.0, E10.4+G99.0
Hospital discharge: ICD-9 2505B
Hospital discharge: ICD-8 $!$
Cause of death: ICD-9 2505B
Cause of death: ICD-8 $!$

958

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

958

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Check minimum number of events None

958

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Include endpoints None

958

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E4_DM1NEU

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 958 433 525
Unadjusted prevalence (%) 0.27 0.22 0.33
Mean age at first event (years) 46.56 43.87 48.79

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 6.22 [3.61, 10.71] 4.6e-11 174
15 years 0.03 3.90 [2.57, 5.91] 1.4e-10 78
5 years 0.01 6.51 [4.20, 10.09] 5.7e-17 47
1 year 0.00 11.72 [6.50, 21.12] 2.6e-16 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1NEU – Type 1 diabetes with neurological complications
GWS hits: 2

Survival analyses between endpoints

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Plot

before Type 1 diabetes with neurological complications
after Type 1 diabetes with neurological complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 1 diabetes with neurological complications

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