Type 1 diabetes without complications

E4_DM1NOCOMP

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E10.9
Hospital discharge: ICD-9 2500B
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E10.9
Cause of death: ICD-9 2500B
Cause of death: ICD-8 $!$

7883

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

7883

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Check minimum number of events None

7883

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Include endpoints None

7883

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E4_DM1NOCOMP

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3
Parent code in ICD-10 E10

Summary Statistics

Key figures

All Female Male
Number of individuals 7883 3853 4030
Unadjusted prevalence (%) 2.22 1.94 2.56
Mean age at first event (years) 29.93 28.29 31.49

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.35 [3.30, 5.74] 2.6e-25 859
15 years 0.02 2.89 [2.29, 3.65] 4.2e-19 381
5 years 0.01 4.55 [3.73, 5.55] 5.9e-51 184
1 year 0.00 8.61 [6.53, 11.36] 1.9e-52 72

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_DM1NOCOMP – Type 1 diabetes without complications
GWS hits:

Survival analyses between endpoints

Plot

before Type 1 diabetes without complications
after Type 1 diabetes without complications

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Drugs most likely to be purchased after Type 1 diabetes without complications