≡ Risteys
R8

Documentation Changelog GitHub Contact & Feedback

Type 2 diabetes with coma

DOID EFO MESH SNOMED PheWeb

E4_DM2COMA

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

↥
FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector

Check conditions None

356077

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 E11.00, E11.01, E11.09
Hospital discharge: ICD-9 2502A
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E11.00, E11.01, E11.09
Cause of death: ICD-9 2502A
Cause of death: ICD-8 $!$

4312

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4312

diagram downward connector

Check minimum number of events None

4312

diagram downward connector

Include endpoints None

4312

diagram downward connector
E4_DM2COMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 4312 1578 2734
Unadjusted prevalence (%) 1.21 0.80 1.74
Mean age at first event (years) 64.02 62.66 64.81

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 5.87 [4.55, 7.57] 3.5e-42 1747
15 years 0.02 2.88 [2.30, 3.60] 2.6e-20 698
5 years 0.01 5.79 [5.03, 6.65] <1e-100 602
1 year 0.00 15.53 [13.29, 18.15] <1e-100 379

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: E4_DM2COMA – Type 2 diabetes with coma
GWS hits: 6

Survival analyses between endpoints

↥

Plot

before Type 2 diabetes with coma
after Type 2 diabetes with coma

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 2 diabetes with coma

↥