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Type 2 diabetes

DOID EFO MESH SNOMED PheWeb

E4_DM2

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E11
Cause of death: ICD-10 E11
Medicine purchases: ATC A10B

59474

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

55131

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Check minimum number of events

Min. number of events 3

55131

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Include endpoints

56469

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E4_DM2

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF3
Parent code in ICD-10 E10-E14
Name in latin Diabetes (mellitus) [obesus/non obesus] adultorum

Similar endpoints

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List of similar endpoints to Type 2 diabetes based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 56469 24744 31725
Unadjusted prevalence (%) 15.87 12.47 20.16
Mean age at first event (years) 58.68 57.27 59.78

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.48 [2.27, 2.71] 3.9e-93 10187
15 years 0.01 1.73 [1.60, 1.87] 2.7e-42 5151
5 years 0.00 2.51 [2.34, 2.70] <1e-100 2421
1 year 0.00 4.63 [4.14, 5.18] <1e-100 847

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM2 – Type 2 diabetes
GWS hits:

Survival analyses between endpoints

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Plot

before Type 2 diabetes
after Type 2 diabetes

loading spinner Loading survival analyses plot