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Type 2 diabetes with neurological complications

DOID EFO MESH SNOMED PheWeb

E4_DM2NEU

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E11.4+, E11.4+G59.0, E11.4+G63.2, E11.4+G73.0, E11.4+G99.0
Hospital discharge: ICD-9 2505A
Hospital discharge: ICD-8 $!$
Cause of death: ICD-9 2505A
Cause of death: ICD-8 $!$

1667

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1667

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Check minimum number of events None

1667

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Include endpoints None

1667

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E4_DM2NEU

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 1667 489 1178
Unadjusted prevalence (%) 0.47 0.25 0.75
Mean age at first event (years) 63.76 64.11 63.62

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 5.45 [4.33, 6.85] 9.5e-48 530
15 years 0.02 2.62 [2.10, 3.26] 9.6e-18 219
5 years 0.01 4.37 [3.35, 5.70] 1.1e-27 170
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM2NEU – Type 2 diabetes with neurological complications
GWS hits: 2

Survival analyses between endpoints

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Plot

before Type 2 diabetes with neurological complications
after Type 2 diabetes with neurological complications

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Drugs most likely to be purchased after Type 2 diabetes with neurological complications

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