Unspecified diabetes with neurological complications

E4_DMNASNEU

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector

Check conditions None

356077

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 E12.4+, E13.4+, E14.4+
Hospital discharge: ICD-9 2505C|2505X
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E12.4+, E13.4+, E14.4+
Cause of death: ICD-9 2505C|2505X
Cause of death: ICD-8 $!$

96

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

96

diagram downward connector

Check minimum number of events None

96

diagram downward connector

Include endpoints None

96

diagram downward connector
E4_DMNASNEU

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

Key figures

All Female Male
Number of individuals 96 29 67
Unadjusted prevalence (%) 0.03 0.01 0.04
Mean age at first event (years) 54.27 52.24 55.15

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_DMNASNEU – Unspecified diabetes with neurological complications
GWS hits:

Survival analyses between endpoints

Plot

before Unspecified diabetes with neurological complications
after Unspecified diabetes with neurological complications

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Unspecified diabetes with neurological complications