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Hyperfunction of pituitary gland

DOID EFO MESH SNOMED PheWeb

E4_HYPERPIT

hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E22
Cause of death: ICD-10 E22

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

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Check minimum number of events None

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Include endpoints

1390

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E4_HYPERPIT

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Hyperfunctio hypophysis

Similar endpoints

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List of similar endpoints to Hyperfunction of pituitary gland based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 1390 1066 324
Unadjusted prevalence (%) 0.39 0.54 0.21
Mean age at first event (years) 38.18 35.51 46.98

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.57 [0.69, 3.60] 2.8e-1 73
15 years 0.01 0.93 [0.44, 1.94] 8.5e-1 23
5 years 0.00 1.80 [0.86, 3.76] 1.2e-1 12
1 year 0.00 13.02 [6.71, 25.26] 3.2e-14 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPERPIT – Hyperfunction of pituitary gland
GWS hits:

Survival analyses between endpoints

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Plot

before Hyperfunction of pituitary gland
after Hyperfunction of pituitary gland

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Drugs most likely to be purchased after Hyperfunction of pituitary gland

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