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Vitamin deficiency

DOID EFO MESH SNOMED PheWeb

E4_VIT_DEF

ascorbic acid deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into scurvy in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E50, E51, E52, E52+F02.89, E53, E54, E55, E56
Cause of death: ICD-10 E50, E51, E52, E52+F02.89, E53, E54, E55, E56

891

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

886

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Check minimum number of events None

886

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Include endpoints

1232

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E4_VIT_DEF

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 1232 703 529
Unadjusted prevalence (%) 0.35 0.35 0.34
Mean age at first event (years) 53.16 49.54 57.98

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.04 [2.64, 6.18] 1.1e-10 234
15 years 0.01 1.81 [1.17, 2.81] 8.2e-3 99
5 years 0.00 3.74 [2.61, 5.38] 8.9e-13 85
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_VIT_DEF – Vitamin deficiency
GWS hits:

Survival analyses between endpoints

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Plot

before Vitamin deficiency
after Vitamin deficiency

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Drugs most likely to be purchased after Vitamin deficiency

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