Vitamin deficiency

VIT_DEF

ascorbic acid deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into scurvy in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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VIT_DEF

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1232 703 529
Unadjusted prevalence (%) 0.35 0.35 0.34
Mean age at first event (years) 53.16 49.54 57.98

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.34 [1.99, 5.62] 5.4e-6 234
15 years 0.01 1.71 [1.04, 2.79] 3.3e-2 99
5 years 0.00 3.80 [2.62, 5.50] 1.7e-12 85
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: VIT_DEF – Vitamin deficiency
GWS hits:

Survival analyses between endpoints

Plot

before Vitamin deficiency
after Vitamin deficiency

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Drugs most likely to be purchased after Vitamin deficiency