Vitamin D deficiency


ascorbic acid deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into scurvy in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 E55
Hospital discharge: ICD-9 268
Hospital discharge: ICD-8 265
Cause of death: ICD-10 E55
Cause of death: ICD-9 268
Cause of death: ICD-8 265


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E50-E64
Name in latin Deficientia vitamini D

Summary Statistics

Key figures

All Female Male
Number of individuals 402 261 141
Unadjusted prevalence (%) 0.11 0.13 0.09
Mean age at first event (years) 44.11 44.23 43.87


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 4.85 [2.18, 10.77] 1.1e-4 29
15 years 0.02 2.09 [0.93, 4.71] 7.5e-2 11
5 years 0.01 4.25 [1.86, 9.69] 5.9e-4 11
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_VIT_D_DEF – Vitamin D deficiency
GWS hits:

Survival analyses between endpoints


before Vitamin D deficiency
after Vitamin D deficiency

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Drugs most likely to be purchased after Vitamin D deficiency