Secondary parkinsonism+Parkinsonism in other disease

G6_PARKSCND

postencephalitic Parkinson disease: Parkinsonism following encephalitis, historically seen as a sequella of encephalitis lethargica (Von Economo Encephalitis). The early age of onset, the rapid progression of symptoms followed by stabilization, and the presence of a variety of other neurological disorders (e.g., sociopathic behavior; TICS; MUSCLE SPASMS; oculogyric crises; hyperphagia; and bizarre movements) distinguish this condition from primary PARKINSON DISEASE. Pathologic features include neuronal loss and gliosis concentrated in the MESENCEPHALON; SUBTHALAMUS; and HYPOTHALAMUS. (From Adams et al., Principles of Neurology, 6th ed, p754)

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G21, G22*, G22*A52.1
Hospital discharge: ICD-9 3321
Hospital discharge: ICD-8 3420[8-9]
Cause of death: ICD-10 G21, G22*, G22*A52.1
Cause of death: ICD-9 3321
Cause of death: ICD-8 3420[8-9]

695

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

695

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Check minimum number of events None

695

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Include endpoints None

695

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G6_PARKSCND

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 695 275 420
Unadjusted prevalence (%) 0.20 0.14 0.27
Mean age at first event (years) 61.38 60.92 61.67

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_PARKSCND – Secondary parkinsonism+Parkinsonism in other disease
GWS hits:

Survival analyses between endpoints

Plot

before Secondary parkinsonism+Parkinsonism in other disease
after Secondary parkinsonism+Parkinsonism in other disease

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Drugs most likely to be purchased after Secondary parkinsonism+Parkinsonism in other disease