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Secondary parkinsonism

DOID EFO MESH SNOMED PheWeb

PD2ND

secondary Parkinson disease: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 G21
Hospital discharge: ICD-9 3321
Cause of death: ICD-10 G21
Cause of death: ICD-9 3321

669

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 9 ; C.O.D: 10, 9

669

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Check minimum number of events None

669

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Include endpoints None

669

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PD2ND

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 G20-G26
Name in latin Parkinsonismus secundarius

Summary Statistics

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Key figures

All Female Male
Number of individuals 669 266 403
Unadjusted prevalence (%) 0.19 0.13 0.26
Mean age at first event (years) 61.85 61.68 61.96

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.53 [2.30, 8.94] 1.3e-5 215
15 years 0.02 2.23 [1.37, 3.62] 1.2e-3 82
5 years 0.01 5.68 [3.97, 8.14] 2.7e-21 89
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: PD2ND – Secondary parkinsonism
GWS hits:

Survival analyses between endpoints

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Plot

before Secondary parkinsonism
after Secondary parkinsonism

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Secondary parkinsonism

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