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Ischaemic heart disease, wide definition

DOID EFO MESH SNOMED PheWeb

I9_IHD

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I20-I25
Hospital discharge: ICD-9 41[0-4]
Hospital discharge: ICD-8 41[0-4]
Cause of death: ICD-10 I21, I22, I23, I24, I25, I46, R96, R98
Cause of death: ICD-9 41[0-4]|798
Cause of death: ICD-8 41[0-4]|798
Cause of death: excluded ICD-9 7980A
KELA reimbursements: KELA codes 206

58578

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

58578

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Check minimum number of events None

58578

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Include endpoints None

58578

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I9_IHD

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 58578 19449 39129
Unadjusted prevalence (%) 16.46 9.80 24.86
Mean age at first event (years) 63.82 64.66 63.40

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.52 [3.25, 3.81] <1e-100 18318
15 years 0.01 2.19 [2.03, 2.37] 8.9e-88 7074
5 years 0.00 3.34 [3.10, 3.59] <1e-100 3598
1 year 0.01 25.83 [23.14, 28.84] <1e-100 4910

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_IHD – Ischaemic heart disease, wide definition
GWS hits: 70

Survival analyses between endpoints

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Plot

before Ischaemic heart disease, wide definition
after Ischaemic heart disease, wide definition

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Ischaemic heart disease, wide definition

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