Interstitial lung disease endpoints

ILD_ENDPOINTS

interstitial lung disease: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

3829

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ILD_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Interstitial lung disease endpoints based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 3829 1488 2341
Unadjusted prevalence (%) 1.08 0.75 1.49
Mean age at first event (years) 65.76 62.62 67.76

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 6.20 [4.91, 7.83] 7.7e-53 1092
15 years 0.01 1.97 [1.55, 2.49] 2.5e-8 304
5 years 0.01 5.47 [4.43, 6.76] 6.8e-56 421
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: ILD_ENDPOINTS – Interstitial lung disease endpoints
GWS hits: 10

Survival analyses between endpoints

Plot

before Interstitial lung disease endpoints
after Interstitial lung disease endpoints

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Drugs most likely to be purchased after Interstitial lung disease endpoints