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Ulcerative colitis

DOID EFO MESH SNOMED PheWeb

K11_ULCER

ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K51
Hospital discharge: ICD-9 556
Hospital discharge: ICD-8 5631|569
Hospital discharge: excluded ICD-9 5564A
Cause of death: ICD-10 K51
Cause of death: ICD-9 556
Cause of death: ICD-8 5631|569
Cause of death: excluded ICD-9 5564A

8249

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

7799

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Check minimum number of events None

7799

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Include endpoints None

7799

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K11_ULCER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K50-K52
Name in latin Colitis ulcerosa

Similar endpoints

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List of similar endpoints to Ulcerative colitis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 7799 4086 3713
Unadjusted prevalence (%) 2.19 2.06 2.36
Mean age at first event (years) 42.77 40.64 45.11

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.24 [0.93, 1.65] 1.5e-1 645
15 years 0.01 0.85 [0.66, 1.10] 2.2e-1 268
5 years 0.00 1.68 [1.32, 2.13] 2.3e-5 139
1 year 0.00 4.40 [3.26, 5.93] 2.5e-22 67

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_ULCER – Ulcerative colitis
GWS hits:

Survival analyses between endpoints

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Plot

before Ulcerative colitis
after Ulcerative colitis

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Drugs most likely to be purchased after Ulcerative colitis

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