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Osteonecrosis

DOID EFO MESH SNOMED PheWeb

M13_OSTEONECROSIS

osteonecrosis: A none disease characterized by death of bone tissue due to a lack of blood supply.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M87
Hospital discharge: ICD-9 7334
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M87
Cause of death: ICD-9 7334
Cause of death: ICD-8 $!$

1249

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1249

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Check minimum number of events None

1249

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Include endpoints None

1249

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M13_OSTEONECROSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M86-M90
Name in latin Osteonecrosis

Summary Statistics

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Key figures

All Female Male
Number of individuals 1249 696 553
Unadjusted prevalence (%) 0.35 0.35 0.35
Mean age at first event (years) 58.97 59.16 58.72

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.10 6.17 [4.12, 9.23] 8.9e-19 122
15 years 0.01 1.93 [1.19, 3.15] 8.2e-3 34
5 years 0.01 5.96 [3.55, 10.00] 1.4e-11 47
1 year 0.00 15.90 [8.67, 29.17] 4.1e-19 29

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_OSTEONECROSIS – Osteonecrosis
GWS hits:

Survival analyses between endpoints

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Plot

before Osteonecrosis
after Osteonecrosis

loading spinner Loading survival analyses plot