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Osteoporosis

DOID EFO MESH SNOMED PheWeb

M13_OSTEOPOROSIS

osteoporosis: A condition of reduced bone mass, with decreased cortical thickness and a decrease in the number and size of the trabeculae of cancellous bone (but normal chemical composition), resulting in increased fracture incidence. Osteoporosis is classified as primary (Type 1, postmenopausal osteoporosis; Type 2, age-associated osteoporosis; and idiopathic, which can affect juveniles, premenopausal women, and middle-aged men) and secondary osteoporosis (which results from an identifiable cause of bone mass loss).

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M80, M81, M82*
Hospital discharge: ICD-9 733[0-1]
Hospital discharge: ICD-8 7230|72391
Cause of death: ICD-10 M80, M81, M82*
Cause of death: ICD-9 733[0-1]
Cause of death: ICD-8 7230|72391

6604

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6493

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Check minimum number of events None

6493

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Include endpoints None

6493

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M13_OSTEOPOROSIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Osteoporosis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 6493 4894 1599
Unadjusted prevalence (%) 1.82 2.47 1.02
Mean age at first event (years) 66.87 67.46 65.09

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 5.00 [4.12, 6.06] 7.1e-60 1280
15 years 0.01 1.71 [1.40, 2.08] 9.7e-8 376
5 years 0.01 4.95 [4.16, 5.88] 1.7e-73 553
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_OSTEOPOROSIS – Osteoporosis
GWS hits: 4

Survival analyses between endpoints

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Plot

before Osteoporosis
after Osteoporosis

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