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Spondylolisthesis/Spondylolysis

DOID EFO MESH SNOMED PheWeb

M13_SPONDYLOLISTHESIS

spondylolisthesis: A condition in which there is forward displacement of a vertebral bone over the on below it.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M43.0, M43.1
Hospital discharge: ICD-9 7384
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M43.0, M43.1
Cause of death: ICD-9 7384
Cause of death: ICD-8 $!$

5136

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5136

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Check minimum number of events None

5136

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Include endpoints None

5136

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M13_SPONDYLOLISTHESIS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 5136 3321 1815
Unadjusted prevalence (%) 1.44 1.67 1.15
Mean age at first event (years) 55.49 55.87 54.81

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.91 [1.22, 2.97] 4.5e-3 246
15 years 0.01 1.35 [0.95, 1.92] 9.2e-2 121
5 years 0.00 2.23 [1.58, 3.14] 5.5e-6 67
1 year 0.00 2.85 [1.68, 4.85] 1.1e-4 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SPONDYLOLISTHESIS – Spondylolisthesis/Spondylolysis
GWS hits: 1

Survival analyses between endpoints

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Plot

before Spondylolisthesis/Spondylolysis
after Spondylolisthesis/Spondylolysis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Spondylolisthesis/Spondylolysis

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