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Spondylopathies

DOID EFO MESH SNOMED PheWeb

M13_SPONDYLOPATHY

ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M45-M49
Cause of death: ICD-10 M45-M49

32767

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

32767

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Check minimum number of events None

32767

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Include endpoints

34654

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M13_SPONDYLOPATHY

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 34654 18461 16193
Unadjusted prevalence (%) 9.74 9.30 10.29
Mean age at first event (years) 58.28 57.64 59.01

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.60 [1.39, 1.83] 1.3e-11 3979
15 years 0.01 1.11 [0.99, 1.25] 7.6e-2 1974
5 years 0.00 1.72 [1.55, 1.91] 7.6e-25 963
1 year 0.00 3.26 [2.81, 3.77] 5.3e-56 342

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SPONDYLOPATHY – Spondylopathies
GWS hits: 16

Survival analyses between endpoints

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Plot

before Spondylopathies
after Spondylopathies

loading spinner Loading survival analyses plot