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Seronegative rheumatoid arthritis

DOID EFO MESH SNOMED PheWeb

RHEUMA_SERONEG

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M06.0
Hospital discharge: ICD-9 7140B
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M06.0
Cause of death: ICD-9 7140B
Cause of death: ICD-8 $!$

3550

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3550

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Check minimum number of events None

3550

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Include endpoints None

3550

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RHEUMA_SERONEG

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M06
Name in latin Arthritis rheumatoides seronegativa

Summary Statistics

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Key figures

All Female Male
Number of individuals 3550 2504 1046
Unadjusted prevalence (%) 1.00 1.26 0.66
Mean age at first event (years) 53.47 51.80 57.45

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.79 [1.32, 2.44] 2.1e-4 338
15 years 0.01 1.31 [1.02, 1.69] 3.8e-2 163
5 years 0.00 1.85 [1.40, 2.45] 1.8e-5 72
1 year 0.00 2.82 [1.75, 4.54] 1.9e-5 20

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_SERONEG – Seronegative rheumatoid arthritis
GWS hits: 3

Survival analyses between endpoints

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Plot

before Seronegative rheumatoid arthritis
after Seronegative rheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Seronegative rheumatoid arthritis

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