≡ Risteys
R8

Documentation Changelog GitHub Contact & Feedback

Rheumatoid arthritis

DOID EFO MESH SNOMED PheWeb

M13_RHEUMA

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

↥
FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector

Check conditions None

356077

diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 M05, M06
Hospital discharge: ICD-9 7140A|7140B|7241|7142
Hospital discharge: ICD-8 712[1-3]
Cause of death: ICD-10 M05, M06
Cause of death: ICD-9 7140A|7140B|7241|7142
Cause of death: ICD-8 712[1-3]

14926

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

11468

diagram downward connector

Check minimum number of events None

11468

diagram downward connector

Include endpoints None

11468

diagram downward connector
M13_RHEUMA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Similar endpoints

↥

Summary Statistics

↥

Key figures

All Female Male
Number of individuals 11468 7724 3744
Unadjusted prevalence (%) 3.22 3.89 2.38
Mean age at first event (years) 52.05 50.17 55.95

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.86 [1.51, 2.30] 9.4e-9 1468
15 years 0.01 1.35 [1.15, 1.59] 2.4e-4 692
5 years 0.00 2.13 [1.83, 2.48] 2.7e-22 321
1 year 0.00 3.32 [2.62, 4.21] 2.2e-23 93

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: M13_RHEUMA – Rheumatoid arthritis
GWS hits: 21

Survival analyses between endpoints

↥

Plot

before Rheumatoid arthritis
after Rheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Rheumatoid arthritis

↥