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Type 2 diabetes, wide definition

DOID EFO MESH SNOMED PheWeb

T2D_WIDE

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

not PANCREATITIS

350432

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Filter registries

Hospital Discharge: ICD-10 E11
Hospital discharge: ICD-9 250.A
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E11
Cause of death: ICD-9 250.A
Cause of death: ICD-8 $!$

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

34172

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T2D_WIDE

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 E10-E14
Name in latin Diabetes (mellitus) [obesus/non obesus] adultorum

Summary Statistics

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Key figures

All Female Male
Number of individuals 34172 13924 20248
Unadjusted prevalence (%) 9.60 7.02 12.87
Mean age at first event (years) 62.71 61.60 63.47

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.81 [3.37, 4.30] <1e-100 8299
15 years 0.01 2.11 [1.89, 2.35] 2.4e-42 3346
5 years 0.00 3.92 [3.61, 4.26] <1e-100 2477
1 year 0.00 12.80 [11.53, 14.22] <1e-100 1728

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T2D_WIDE – Type 2 diabetes, wide definition
GWS hits: 103

Survival analyses between endpoints

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Plot

before Type 2 diabetes, wide definition
after Type 2 diabetes, wide definition

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Drugs most likely to be purchased after Type 2 diabetes, wide definition

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