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Ulcerative ileocolitis

DOID EFO MESH SNOMED PheWeb

ULCERILEO

Crohn's disease: A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn disease most commonly involves the terminal ileum; the colon is the second most common site of involvement.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 K51.1
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K51.1
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

1142

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1142

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Check minimum number of events None

1142

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Include endpoints None

1142

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ULCERILEO

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K51
Name in latin Ileocolitis ulcerosa [chronica]

Summary Statistics

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Key figures

All Female Male
Number of individuals 1142 599 543
Unadjusted prevalence (%) 0.32 0.30 0.35
Mean age at first event (years) 43.26 40.93 45.83

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 4.81 [3.13, 7.40] 9.0e-13 59
15 years 0.02 2.47 [1.59, 3.82] 5.4e-5 26
5 years 0.01 3.97 [2.19, 7.19] 5.4e-6 16
1 year 0.00 12.67 [6.14, 26.16] 6.7e-12 10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: ULCERILEO – Ulcerative ileocolitis
GWS hits: 2

Survival analyses between endpoints

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Plot

before Ulcerative ileocolitis
after Ulcerative ileocolitis

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Drugs most likely to be purchased after Ulcerative ileocolitis

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