Type 2 diabetes, definitions combined

T2D

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

not E4_DM1

346486

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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Include endpoints

50854

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T2D

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 50854 22274 28580
Unadjusted prevalence (%) 14.29 11.23 18.16
Mean age at first event (years) 60.13 58.81 61.16

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.42 [2.20, 2.66] 2.5e-74 8983
15 years 0.01 1.68 [1.55, 1.83] 1.1e-36 4543
5 years 0.00 2.50 [2.33, 2.69] <1e-100 2230
1 year 0.00 4.76 [4.26, 5.33] <1e-100 801

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T2D – Type 2 diabetes, definitions combined
GWS hits: 175

Survival analyses between endpoints

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Plot

before Type 2 diabetes, definitions combined
after Type 2 diabetes, definitions combined

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Drugs most likely to be purchased after Type 2 diabetes, definitions combined

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