Type 2 diabetes, definitions combined

T2D

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector
diagram bullet

Check conditions

not E4_DM1

346486

diagram downward connector

Filter registries None

0

diagram downward connector

Check pre-conditions, main-only, mode, ICD version None

0

diagram downward connector

Check minimum number of events None

0

diagram downward connector
diagram bullet diagram downward connector

Include endpoints

50854

diagram downward connector
T2D

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 50854 22274 28580
Unadjusted prevalence (%) 14.29 11.23 18.16
Mean age at first event (years) 60.13 58.81 61.16

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.42 [2.20, 2.66] 2.5e-74 8983
15 years 0.01 1.68 [1.55, 1.83] 1.1e-36 4543
5 years 0.00 2.50 [2.33, 2.69] <1e-100 2230
1 year 0.00 4.76 [4.26, 5.33] <1e-100 801

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: T2D – Type 2 diabetes, definitions combined
GWS hits: 175

Survival analyses between endpoints

Plot

before Type 2 diabetes, definitions combined
after Type 2 diabetes, definitions combined

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 2 diabetes, definitions combined