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Type 2 diabetes, strict (exclude DM1)

DOID EFO MESH SNOMED PheWeb

E4_DM2_STRICT

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

not E4_DM1

346486

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Filter registries

Medicine purchases: ATC A10B

51160

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Check pre-conditions, main-only, mode, ICD version None

46348

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Check minimum number of events

Min. number of events 3

46348

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Include endpoints

50778

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E4_DM2_STRICT

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 50778 22236 28542
Unadjusted prevalence (%) 14.27 11.21 18.14
Mean age at first event (years) 60.12 58.80 61.15

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.33 [2.11, 2.56] 6.2e-68 8976
15 years 0.01 1.64 [1.52, 1.78] 1.6e-33 4543
5 years 0.00 2.48 [2.30, 2.66] <1e-100 2227
1 year 0.00 4.72 [4.22, 5.28] <1e-100 797

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM2_STRICT – Type 2 diabetes, strict (exclude DM1)
GWS hits:

Survival analyses between endpoints

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Plot

before Type 2 diabetes, strict (exclude DM1)
after Type 2 diabetes, strict (exclude DM1)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Type 2 diabetes, strict (exclude DM1)

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