Diabetic retinopathy

DM_RETINOPATHY

diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions

DIABETES_FG

60969

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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DM_RETINOPATHY

Extra metadata

First used in FinnGen datafreeze DF8

Similar endpoints

List of similar endpoints to Diabetic retinopathy based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 9229 4025 5204
Unadjusted prevalence (%) 2.59 2.03 3.31
Mean age at first event (years) 56.64 55.44 57.57

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.25 [2.68, 3.94] 5.2e-33 1693
15 years 0.01 2.04 [1.73, 2.41] 4.9e-17 846
5 years 0.00 3.14 [2.70, 3.66] 1.0e-49 497
1 year 0.00 3.69 [2.94, 4.62] 7.4e-30 117

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: DM_RETINOPATHY – Diabetic retinopathy
GWS hits:

Survival analyses between endpoints

Plot

before Diabetic retinopathy
after Diabetic retinopathy

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Drugs most likely to be purchased after Diabetic retinopathy