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Familial hypercholesterolemia

PheWeb

E4_FH

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E78.00
Hospital discharge: ICD-9 2720A
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E78.00
Cause of death: ICD-9 2720A
Cause of death: ICD-8 $!$

4598

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

4598

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Check minimum number of events None

4598

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Include endpoints None

4598

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E4_FH

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF6v3

Summary Statistics

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Key figures

All Female Male
Number of individuals 4598 1849 2749
Unadjusted prevalence (%) 1.29 0.93 1.75
Mean age at first event (years) 64.21 63.94 64.39

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.60 [1.40, 4.81] 2.3e-3 861
15 years 0.01 1.67 [1.08, 2.59] 2.1e-2 398
5 years 0.00 3.74 [2.80, 4.98] 2.8e-19 280
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_FH – Familial hypercholesterolemia
GWS hits: 21

Survival analyses between endpoints

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Plot

before Familial hypercholesterolemia
after Familial hypercholesterolemia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Familial hypercholesterolemia

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