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Pure hypercholesterolaemia

DOID MESH PheWeb

E4_HYPERCHOL

No definition available.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 E78.0
Hospital discharge: ICD-9 2720
Hospital discharge: ICD-8 2720
Cause of death: ICD-10 E78.0
Cause of death: ICD-9 2720
Cause of death: ICD-8 2720

23178

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

23178

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Check minimum number of events None

23178

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Include endpoints

23178

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E4_HYPERCHOL

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E78
Name in latin Hypercholesterolaemia pura

Summary Statistics

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Key figures

All Female Male
Number of individuals 23178 10099 13079
Unadjusted prevalence (%) 6.51 5.09 8.31
Mean age at first event (years) 65.27 65.46 65.12

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.94 [2.41, 3.59] 3.1e-26 3040
15 years 0.01 1.37 [1.16, 1.61] 2.0e-4 1161
5 years 0.00 3.33 [2.94, 3.76] 8.2e-82 1115
1 year 0.00 9.63 [8.38, 11.07] <1e-100 633

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPERCHOL – Pure hypercholesterolaemia
GWS hits: 40

Survival analyses between endpoints

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Plot

before Pure hypercholesterolaemia
after Pure hypercholesterolaemia

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Drugs most likely to be purchased after Pure hypercholesterolaemia

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