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Diabetic retinopathy

DOID EFO MESH SNOMED PheWeb

H7_RETINOPATHYDIAB

diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital discharge: ICD-9 3620
Hospital discharge: ICD-8 $!$
Cause of death: ICD-9 3620
Cause of death: ICD-8 $!$

6200

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6169

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Check minimum number of events None

6169

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Include endpoints

6169

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H7_RETINOPATHYDIAB

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 6169 2738 3431
Unadjusted prevalence (%) 1.73 1.38 2.18
Mean age at first event (years) 49.66 46.99 51.79

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.35 [3.50, 5.42] 8.6e-40 1175
15 years 0.02 2.94 [2.49, 3.47] 4.0e-37 597
5 years 0.01 4.53 [3.90, 5.26] 1.2e-86 322
1 year 0.00 5.28 [4.10, 6.80] 7.4e-38 74

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_RETINOPATHYDIAB – Diabetic retinopathy
GWS hits: 17

Survival analyses between endpoints

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Plot

before Diabetic retinopathy
after Diabetic retinopathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetic retinopathy

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