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Hypothyroidism, levothyroxin purchases

DOID EFO MESH SNOMED PheWeb

HYPOTHY_LEVOTHY

hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Medicine purchases: ATC H03AA01

46573

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Check pre-conditions, main-only, mode, ICD version None

42759

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Check minimum number of events

Min. number of events 3

42759

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Include endpoints None

42759

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HYPOTHY_LEVOTHY

Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

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List of similar endpoints to Hypothyroidism, levothyroxin purchases based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 42759 34190 8569
Unadjusted prevalence (%) 12.02 17.23 5.44
Mean age at first event (years) 51.74 50.12 58.17

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.28 [1.11, 1.49] 1.0e-3 3197
15 years 0.01 0.96 [0.85, 1.09] 5.6e-1 1592
5 years 0.00 1.70 [1.51, 1.91] 4.8e-18 774
1 year 0.00 1.29 [1.04, 1.62] 2.3e-2 104

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: HYPOTHY_LEVOTHY – Hypothyroidism, levothyroxin purchases
GWS hits:

Survival analyses between endpoints

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Plot

before Hypothyroidism, levothyroxin purchases
after Hypothyroidism, levothyroxin purchases

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Drugs most likely to be purchased after Hypothyroidism, levothyroxin purchases

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