Hypothyroidism and >3 levothyroxin purchases

HYPOTHY_PURCHASE

hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

FinnGen phenotype data

356077 individuals

diagram downward connector

Apply sex-specific rule None

356077

diagram downward connector
diagram bullet

Check conditions

HYPOTHYROIDISM

43484

diagram downward connector

Filter registries None

0

diagram downward connector

Check pre-conditions, main-only, mode, ICD version None

0

diagram downward connector

Check minimum number of events None

0

diagram downward connector
diagram bullet diagram downward connector

Include endpoints

42759

diagram downward connector
HYPOTHY_PURCHASE

Extra metadata

First used in FinnGen datafreeze DF3

Similar endpoints

List of similar endpoints to Hypothyroidism and >3 levothyroxin purchases based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 42759 34190 8569
Unadjusted prevalence (%) 12.02 17.23 5.44
Mean age at first event (years) 51.74 50.12 58.17

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.49 [1.31, 1.70] 7.0e-10 3197
15 years 0.01 1.11 [0.99, 1.24] 7.9e-2 1592
5 years 0.00 1.79 [1.59, 2.02] 4.7e-22 774
1 year 0.00 1.36 [1.09, 1.70] 6.3e-3 104

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: HYPOTHY_PURCHASE – Hypothyroidism and >3 levothyroxin purchases
GWS hits:

Survival analyses between endpoints

Plot

before Hypothyroidism and >3 levothyroxin purchases
after Hypothyroidism and >3 levothyroxin purchases

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypothyroidism and >3 levothyroxin purchases