Hypothyroidism, other/unspecified


hypothyroidism: Abnormally low levels of thyroid hormone.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 E03.80, E03.82, E03.89, E03.9, E03.9+F02.89, E03.9+G13.2, E03.9+M14.5
Hospital discharge: ICD-9 244[8-9]
Hospital discharge: ICD-8 244
Hospital discharge: excluded ICD-9 2448A|2448B
Hospital discharge: excluded ICD-8 24409
Cause of death: ICD-9 244[8-9]
Cause of death: ICD-8 244
Cause of death: excluded ICD-9 2448A|2448B
KELA reimbursements: KELA codes 104
KELA reimbursements: ICD-10 E03
Medicine purchases: ATC H03A


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events

Min. number of events 3


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Hypothyroidism, other/unspecified based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

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Summary Statistics

Key figures

All Female Male
Number of individuals 43382 34626 8756
Unadjusted prevalence (%) 12.19 17.45 5.56
Mean age at first event (years) 51.66 50.02 58.15


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.32 [1.14, 1.53] 2.4e-4 3273
15 years 0.01 1.01 [0.90, 1.14] 8.4e-1 1599
5 years 0.00 1.83 [1.64, 2.05] 4.4e-26 797
1 year 0.00 1.79 [1.47, 2.19] 5.8e-9 138

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_HYTHYNAS – Hypothyroidism, other/unspecified
GWS hits: 126

Survival analyses between endpoints


before Hypothyroidism, other/unspecified
after Hypothyroidism, other/unspecified

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Drugs most likely to be purchased after Hypothyroidism, other/unspecified