Aortic aneurysm

I9_AORTANEUR

aortic aneurysm: A ruptured aneurysm located in the wall of the proximal portion of the descending aorta proceeding from the arch of the aorta.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I71.1, I71.2, I71.3, I71.4, I71.5, I71.6, I71.8, I71.9
Hospital discharge: ICD-9 441[1-9]|0930A
Hospital discharge: ICD-8 0930|441
Cause of death: ICD-10 I71.1, I71.2, I71.3, I71.4, I71.5, I71.6, I71.8, I71.9
Cause of death: ICD-9 441[1-9]|0930A
Cause of death: ICD-8 0930|441

6641

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6624

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Check minimum number of events None

6624

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Include endpoints

7819

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I9_AORTANEUR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 7819 1390 6429
Unadjusted prevalence (%) 2.20 0.70 4.09
Mean age at first event (years) 67.74 65.43 68.23

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 5.01 [4.12, 6.09] 1.1e-58 2377
15 years 0.01 2.16 [1.86, 2.51] 2.7e-24 846
5 years 0.00 3.69 [3.28, 4.15] <1e-100 658
1 year 0.00 19.41 [17.14, 21.98] <1e-100 766

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: I9_AORTANEUR – Aortic aneurysm
GWS hits: 12

Survival analyses between endpoints

Plot

before Aortic aneurysm
after Aortic aneurysm

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