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Hypertensive Renal Disease

DOID EFO MESH SNOMED PheWeb

I9_HYPTENSRD

nephrosclerosis: Hardening of the walls of the small arteries and arterioles (small arteries that convey blood from arteries to the even smaller capillaries) of the kidney. This condition is caused by hypertension (high blood pressure)

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I12
Hospital discharge: ICD-9 4039A
Hospital discharge: ICD-8 40399
Cause of death: ICD-10 I12
Cause of death: ICD-9 4039A
Cause of death: ICD-8 40399

941

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

941

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Check minimum number of events None

941

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Include endpoints None

941

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I9_HYPTENSRD

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I10-I15
Name in latin Morbus hypertensivus renalis

Summary Statistics

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Key figures

All Female Male
Number of individuals 941 299 642
Unadjusted prevalence (%) 0.26 0.15 0.41
Mean age at first event (years) 61.32 58.29 62.74

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 5.27 [3.15, 8.83] 2.7e-10 320
15 years 0.01 2.08 [1.43, 3.02] 1.1e-4 92
5 years 0.01 4.89 [3.48, 6.85] 3.5e-20 88
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HYPTENSRD – Hypertensive Renal Disease
GWS hits: 2

Survival analyses between endpoints

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Plot

before Hypertensive Renal Disease
after Hypertensive Renal Disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypertensive Renal Disease

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