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Hypertension

DOID EFO MESH SNOMED PheWeb

I9_HYPTENS

hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 I10-I15, I67.4
Hospital discharge: ICD-9 4019X|4029A|4029B|4039A|4040A|4059A|4059B|4372A|4059X
Hospital discharge: ICD-8 400|401|402|403|404
Cause of death: ICD-10 I10-I15, I67.4
Cause of death: ICD-9 4019X|4029A|4029B|4039A|4040A|4059A|4059B|4372A|4059X
Cause of death: ICD-8 400|401|402|403|404
KELA reimbursements: KELA codes 205

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

101652

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I9_HYPTENS

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Similar endpoints

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Summary Statistics

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Key figures

All Female Male
Number of individuals 101652 47887 53765
Unadjusted prevalence (%) 28.57 24.14 34.16
Mean age at first event (years) 57.02 56.74 57.28

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.09 [1.94, 2.24] 3.2e-92 18571
15 years 0.01 1.40 [1.31, 1.50] 1.2e-21 8104
5 years 0.00 2.18 [2.04, 2.33] <1e-100 3990
1 year 0.00 6.29 [5.67, 6.98] <1e-100 2120

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HYPTENS – Hypertension
GWS hits: 208

Survival analyses between endpoints

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Plot

before Hypertension
after Hypertension

loading spinner Loading survival analyses plot