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Asthma (only as main-diagnosis)

DOID EFO MESH SNOMED PheWeb

J10_ASTHMA_MAIN

asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

Endpoint definition

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FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 J45, J46
Hospital discharge: ICD-9 493
Hospital discharge: ICD-8 493
Cause of death: ICD-10 J45, J46
Cause of death: ICD-9 493
Cause of death: ICD-8 493

38560

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Check pre-conditions, main-only, mode, ICD version

Check only main diagnosis Yes, side diagnoses are not checked
Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

31367

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Check minimum number of events None

31367

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Include endpoints None

31367

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J10_ASTHMA_MAIN

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 31367 19348 12019
Unadjusted prevalence (%) 8.82 9.75 7.64
Mean age at first event (years) 42.26 41.06 44.19

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.88 [1.63, 2.17] 3.6e-18 3090
15 years 0.01 1.35 [1.20, 1.53] 1.3e-6 1421
5 years 0.00 2.19 [1.93, 2.49] 3.0e-33 686
1 year 0.00 3.52 [2.95, 4.20] 1.9e-44 209

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: J10_ASTHMA_MAIN – Asthma (only as main-diagnosis)
GWS hits:

Survival analyses between endpoints

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Plot

before Asthma (only as main-diagnosis)
after Asthma (only as main-diagnosis)

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Drugs most likely to be purchased after Asthma (only as main-diagnosis)

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