Other specified disorders of muscle

M13_MUSCLEDISNAS

myopathy: a disease of the muscle in which the muscle fibers do not function properly. This results in muscular weakness.

Endpoint definition

FinnGen phenotype data

356077 individuals

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Apply sex-specific rule None

356077

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Check conditions None

356077

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Filter registries

Hospital Discharge: ICD-10 M62.8, M62.9
Hospital discharge: ICD-9 728[8-9]
Hospital discharge: ICD-8 733
Hospital discharge: excluded ICD-8 733|777[0-1]|73390
Cause of death: ICD-10 M62.8, M62.9
Cause of death: ICD-9 728[8-9]
Cause of death: ICD-8 733
Cause of death: excluded ICD-8 733|777[0-1]|73390

3054

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

748

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Check minimum number of events None

748

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Include endpoints None

748

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M13_MUSCLEDISNAS

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 748 390 358
Unadjusted prevalence (%) 0.21 0.20 0.23
Mean age at first event (years) 43.59 43.99 43.15

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.21 [1.08, 4.51] 3.0e-2 90
15 years 0.01 1.09 [0.56, 2.11] 8.0e-1 27
5 years 0.00 1.91 [0.99, 3.66] 5.2e-2 14
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_MUSCLEDISNAS – Other specified disorders of muscle
GWS hits:

Survival analyses between endpoints

Plot

before Other specified disorders of muscle
after Other specified disorders of muscle

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Drugs most likely to be purchased after Other specified disorders of muscle